WeeklySA_AdminCONDITION: Treatment of malnutrition has so far focused on food, providing nutrient-rich meals. Yet, while these strategies remain essential, they don’t always restore healthy growth…
By Own Correspondent
LA JOLLA, California — Millions of children around the world fail to grow as tall as they should, even when food is available – as a result of a condition known as stunted growth, which affects about one in five children under age five globally.
Scientists have long blamed poor nutrition as the main culprit, but that explanation has never been the full story. Two children might eat the same meals, yet one will thrive while the other lags behind.
A new study published in Cell points to a hidden factor: the trillions of bacteria that live in the human gut. Researchers at The Salk Institute for Biological Studies, in collaboration with scientists from Washington University and the University of California, San Diego, found that children whose growth faltered had very different gut microbes compared to those who grew normally.
The findings suggest that the microbiome — the vast community of bacteria, viruses, and other microorganisms inside us — may influence whether a child reaches their expected height.
While the results don’t prove causation, they open an intriguing new chapter in the fight against malnutrition. By studying gut bacteria at a level of detail never achieved before, scientists are piecing together how microscopic life inside us could affect something as visible as a child’s growth.
To uncover these microbial clues, the research team turned to a powerful new tool: culture-independent meta-pangenomics. Traditional microbiome studies often rely on short fragments of DNA or on growing bacteria in the lab, methods that miss much of the microbial diversity and genetic information. This new approach, by contrast, uses long-read DNA sequencing to piece together nearly complete microbial genomes directly from stool samples.
From just 47 samples collected over 11 months from Malawian toddlers, the team reconstructed an astonishing 986 complete microbial genomes, many of which came from species never described before. These genomes, called cMAGs, give scientists a detailed map of which microbes are present and what genes they carry.
The researchers then tested these insights in an expanded validation group of 42 children. This combination of deep sequencing and broader follow-up made the study one of the largest and most detailed microbiome resources created for understanding childhood undernutrition.
Study authors noticed a clear pattern in the results. Children whose height-for-age Z scores declined over the study period, a standard measure of growth faltering, had less stable microbial genomes than those who grew normally.
In other words, the microbial communities in struggling children seemed to churn and change more, while those in healthier children remained more stable.
This genome instability could signal an unhealthy gut environment. When microbes are constantly shifting, the body may lose access to essential nutrients or experience ongoing low-level inflammation. Both can interfere with growth.
The researchers also found that breastfeeding status strongly shaped microbial communities, as did the child’s village of origin. Even within a small geographic region, local differences in diet, environment, and culture appeared to leave their mark on the microbiome.
Gut bacteria are more than passive passengers in our bodies. They help break down food, produce vitamins, and generate amino acids that humans can’t make themselves. Some even influence how our immune systems develop.
When children lack beneficial strains, they may miss out on these invisible but essential services. For example, certain bacteria identified in the study were linked to better growth outcomes because they carried genes that help them interact positively with the host. Others were connected to growth faltering, possibly by promoting inflammation or competing with the body for nutrients.
The study also showed that microbes evolve over time. Genes can be gained or lost, and bacterial populations can shift depending on whether a child is breastfed, weaned, or exposed to seasonal changes in diet. These dynamics may explain why interventions that work in one place or one age group don’t always succeed elsewhere.
For decades, treatment of malnutrition has focused on food: providing nutrient-rich meals, therapeutic milk, or fortified supplements. These strategies remain essential, but they don’t always restore healthy growth.
The new research shows that the gut microbiome may be a missing piece of the puzzle. If future trials confirm that specific microbes support growth, doctors might one day prescribe targeted probiotics or microbiome-based therapies alongside nutrition programs. Instead of only giving food, treatment could also aim to seed or stabilise the right gut bacteria.
This concept isn’t entirely new. Previous small studies have hinted at links between gut bacteria and child growth. But the level of detail provided by long-read sequencing is unprecedented. By examining entire microbial genomes, scientists can pinpoint, not just which species are present, but which genes may actually drive growth outcomes.
Despite the promise, the researchers are careful to stress that their study shows association, not causation. Just because a child’s slow growth coincides with microbial instability does not mean one directly causes the other. Other factors such as poverty, sanitation, infections, or limited access to healthcare all shape both nutrition and the microbiome.
The study was also conducted in a relatively small group of Malawian children. While the results are compelling, larger and more diverse studies are needed to know whether the same patterns apply globally. The next step will be controlled clinical trials to test whether changing children’s microbiomes can actually improve their growth.
Childhood stunting is not just a matter of height. It carries long-term consequences, including poorer cognitive development, reduced school performance, and lower economic productivity in adulthood. According to UNICEF, nearly 150 million children under five are stunted worldwide, with the highest rates in South Asia and sub-Saharan Africa.
If gut microbes turn out to be part of the solution, this could reshape public health strategies. Nutritional interventions might be paired with microbial ones, potentially improving outcomes for millions of children. Even if microbiome therapies prove only partially effective, they could complement food-based programs in meaningful ways.
This study doesn’t provide a cure for malnutrition, but it does highlight the gut as a critical frontier in child health research.
Our long-term health is certainly not determined only by what we eat, but also by the microscopic life within us. As researchers continue to map the genomes of gut bacteria, they may find new ways to help children everywhere grow to their full potential. – StudyFinds
